Inspired by the Spider-Man film trilogy and the classic Spider-Man comics, Spider-Man: Friend or Foe challenges players to defeat and then join forces with notorious movie nemeses including Doc Ock, Green Goblin, Venom and Sandman, and embark on an epic quest to overcome a worldwide evil threat.

Remy and Emile plead the case for rats by illustrating the historical and scientific facts about the species and their interaction with humans.