Her parents being zoologists, Cady Heron has never known what "high school" truly meant. She lived her first 15 years in the African jungle, home-schooled, living life with only her parents and the animals of the wilderness, knowing all of the rules of survival. However, when she moves out of Africa, she has to learn the rules of high school, a jungle in itself. She instantly makes friends with two sweet teenagers, Damian and Janis, who, in the terms of the high school, were in the "out crowd."