Lopez Tonight is an American late-night television talk show hosted by comedian George Lopez. The hour-long program premiered on November 9, 2009, on cable network TBS. Lopez is the first Mexican-American to host a late-night talk show on an English-language network in the United States. The show features audience interaction using a high-energy format. The program airs Monday through Thursday at 12:00 am Midnight Eastern and Pacific, immediately following Conan.